ODM-201 (BAY-1841788, Darolutamide) | AR antagonist | Probechem Biochemicals

Chemical Structure : ODM-201

CAS No.: 1297538-32-9

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ODM-201 (BAY-1841788;Darolutamide)

货号: PC-45113Not For Human Use, Lab Use Only.

ODM-201 (BAY-1841788, Darolutamide) is a potent wt/mutant androgen receptor (AR) inhibitor with Ki of 11 nM.

规格	价格	库存
5 mg	￥580	In stock
10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2580	In stock
100 mg	￥3980	In stock
250 mg		Get quote

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生物&药学活性

ODM-201 (BAY-1841788, Darolutamide) is a potent wt/mutant androgen receptor (AR) inhibitor with Ki of 11 nM.
ODM-201 inhibits wtAR/AR(F876L) with IC50 of 65/66 nM respectively, weak inhibition on AR(W741L) and AR(T877A).
ODM-201 inhibits the nuclear translocation of AR and more efficaciously than enzalutamide or ARN-509 in VCaP cell line proliferation assay。
ODM-201 reduces the growth of AR-overexpressing VCaP prostate cancer cells both in vitro and in a castration-resistant VCaP xenograft model.

物理化学性质&存储条件

分子量	398.8462
分子式	C19H19ClN6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 44 mg/mL
Chemical Name/SMILES	1H-Pyrazole-3-carboxamide, N-[(1S)-2-[3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl]-1-methylethyl]-5-(1-hydroxyethyl)-

参考文献

1. Moilanen AM, et al. Sci Rep. 2015 Jul 3;5:12007.

2. Fizazi K, et al. Lancet Oncol. 2014 Aug;15(9):975-85.

3. Cancer Discov. 2014 Sep;4(9):OF10.

ODM-201 (BAY-1841788;Darolutamide)

生物&药学活性

物理化学性质&存储条件

参考文献

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ODM-201 (BAY-1841788;Darolutamide)

生物&药学活性

物理化学性质&存储条件

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