ODH-08

Chemical Structure : ODH-08

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货号: PC-21695Not For Human Use, Lab Use Only.

ODH-08 is a novel specific small molecule ligand and agonist of RORα with KD value of 8.4 um, shows potent antifibrotic effect.

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生物&药学活性

ODH-08 is a novel specific small molecule ligand and agonist of RORα with KD value of 8.4 um, shows potent antifibrotic effect.
ODH-08 does not activate other nuclear receptors involved in lipid metabolism such as PPARα, PPARγ, PPARδ, and LXRα.
ODH-08 reduces hepatic collagen deposition and expression levels of fibrogenic markers such as α-smooth muscle actin and collagen type I alpha 1 chain in Western diet-fed mice.
ODH-08 suppresses the expression of fibrogenic proteins in hepatic stellate cells (HSCs).
ODH-08 suppresses the activity of SMAD2 and 3, which are the primary downstream proteins of transforming growth factor β.

物理化学性质&存储条件

分子量	343.49
分子式	C19H25N3OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-benzyloxybenzyl)-3-(2-dimethylaminoethyl)-thiourea

参考文献

1. Haena Choi, et al. Life Sci. 2024 Jan 17:122443.

ODH-08

生物&药学活性

物理化学性质&存储条件

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ODH-08

生物&药学活性

物理化学性质&存储条件

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