OCP-001 | HDAC1 inhibitor | Probechem Biochemicals

Chemical Structure : OCP-001

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OCP-001 (OCP001)

货号: PC-25393Not For Human Use, Lab Use Only.

OCP-001 is a potent, highly selective HDAC1 inhibitor, dose-dependently inhibits osteoclast differentiation.

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250 mg		Get quote

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生物&药学活性

OCP-001 is a potent, highly selective HDAC1 inhibitor, dose-dependently inhibits osteoclast differentiation.
OCP-001 dose-dependently suppresses RAW264.7 cell viability with IC50 of 108 uM.
OCP-001 shows no significant inhibition for HDAC2, HDAC3, or HDAC8.
OCP-001 suppresses HADC-mediated deacetylation, thereby preserving H3 acetylation levels in RAW264.7 cells.
OCP-001 treatment (10 uM) inhibits osteoclast differentiation and the expression of osteoclast-related genes.
OCP-001 (10 μg/kg) suppresses OVX-induced bone loss and bone microstructural degradation in ovariectomized (OVX) mice.
OCP-001 regulates bone metabolism, improves trabecular microarchitecture, and inhibits osteoclast differentiation in vivo.

物理化学性质&存储条件

分子量	539.63
分子式	C29H37N3O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethyl-4-(4-((8-(hydroxyamino)-8-oxooctyl)oxy)phenyl)isoxazole-3-carboxamide

参考文献

1. Yuan H, et al. Arch Gerontol Geriatr. 2025 Aug 29;139:106020.

OCP-001 (OCP001)

生物&药学活性

物理化学性质&存储条件

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OCP-001 (OCP001)

生物&药学活性

物理化学性质&存储条件

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