OBR-5-340

Chemical Structure : OBR-5-340

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货号: PC-21696Not For Human Use, Lab Use Only.

OBR-5-340 is a potent, orally bioavailable inhibitor targeting capsid of Rhino- and Enteroviruses,exhibits broad-spectrum antiviral activity against of enteroviruses and rhinoviruses.

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生物&药学活性

OBR-5-340 is a potent, orally bioavailable inhibitor targeting capsid of Rhino- and Enteroviruses,exhibits broad-spectrum antiviral activity against of enteroviruses and rhinoviruses.
OBR-5-340 strongly inhibits the cytopathic effect of the pleconaril-resistant CVB3 Nancy (L1092[4c]) as well as pleconaril-susceptible CVB3 97927 (I1092) with IC50 values of 0.16 and 1.05 μM, respectively.
OBR-5-340 shows highest activities against high-level pleconaril-resistant viruses including RV5, RV42, RV44, RV48, and RV69 with IC50 values of 0.04 to 0.64 uM.
OBR-5-340 exerts a strong antiviral effect in a model of CVB3-induced chronic myocarditis in NMRI mice.
OBR-5-340 inhibits a broad-spectrum of EVs and RVs, helps to overcome the resistance of known capsid inhibitors, and does not exert an effect on relevant cytochrome isoforms.

物理化学性质&存储条件

分子量	370.34
分子式	C18H13F3N6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(4-trifluoromethylphenyl)amino-6-phenylpyrazolo[3,4-d]pyrimidine-4-amine

参考文献

1. Makarov VA, et al. ChemMedChem. 2015 Oct;10(10):1629-34.

2. Wald J, et al. Proc Natl Acad Sci U S A. 2019 Sep 17;116(38):19109-19115.

OBR-5-340

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OBR-5-340

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