OBP-801 |CAS:328548-11-4 Probechem Biochemicals

Chemical Structure : OBP-801

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OBP-801 (OBP801;YM 753;Spiruchostatin A)

货号: PC-61957Not For Human Use, Lab Use Only.

OBP-801 (YM 753;Spiruchostatin A) is a novel cyclic-peptide-based HDAC inhibitor with IC50 of 2 nM.

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生物&药学活性

OBP-801 (YM 753;Spiruchostatin A) is a novel cyclic-peptide-based HDAC inhibitor with IC50 of 2 nM; significantly inhibits the cell growth on comparison with each agent alone and synergistically increased apoptosis with the induction of Bim; significantly suppresses tumor growth in vivo.

Kidney Cancer

Phase 1 Clinical

物理化学性质&存储条件

分子量	473.603
分子式	C20H31N3O6S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1S,5S,6R,9S,20R,E)-5-hydroxy-6-isopropyl-20-methyl-2-oxa-11,12-dithia-7,19,22-triazabicyclo[7.7.6]docos-15-ene-3,8,18,21-tetraone

参考文献

1. Shindoh N, et al. Int J Oncol. 2008 Mar;32(3):545-55.

2. Yoshioka T, et al. Gynecol Oncol. 2013 May;129(2):425-32.

3. Furutani A, et al. Oncol Res. 2014;21(5):281-6.

4. Akiyama M, et al. Oncol Res. 2017 Sep 21;25(8):1245-1252.

OBP-801 (OBP801;YM 753;Spiruchostatin A)

生物&药学活性

物理化学性质&存储条件

参考文献

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OBP-801 (OBP801;YM 753;Spiruchostatin A)

生物&药学活性

物理化学性质&存储条件

参考文献

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