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首页-小分子抑制剂&激动剂-GPCR-Prostaglandin Receptor-OBE022
OBE022

Chemical Structure : OBE022

CAS No.: 2005486-31-5

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OBE022 (Ebopiprant, OBE-022)

货号: PC-35079Not For Human Use, Lab Use Only.

OBE022 (Ebopiprant, OBE-022) is a potent, highly selective, orally active antagonist of the contractile PGF2α prostaglandin receptor with Kb of 5.9 nM, shows no activity for other human PG receptors subtypes.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    OBE022 (Ebopiprant, OBE-022) is a potent, highly selective, orally active antagonist of the contractile PGF2α prostaglandin receptor with Kb of 5.9 nM, shows no activity for other human PG receptors subtypes.
    OBE022 inhibits spontaneous, oxytocin- and PGF2α-induced human myometrial contractions alone and is more effective in combination with atosiban or nifedipine.
    OBE022 reduces spontaneous contractions in near-term pregnant rat, OBE022 delayed RU486-induced parturition and exerted synergistic effects in combination with nifedipine.
    OBE022 exhibits potent tocolytic effects on human tissues ex vivo and animal models in vivo without causing the adverse fetal side effects.

    物理化学性质&存储条件

    分子量 599.74
    分子式 C30H34FN3O5S2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-2-Amino-3-methyl-butyric acid (S)-3-{[(S)-3-(biphenyl-4-sulfonyl)-thiazolidine-2-carbonyl]-amino}-3-(4-fluoro-phenyl)-propyl ester

    参考文献

    1. Pohl O, et al. J Pharmacol Exp Ther. 2018 May 18. pii: jpet.118.247668.

    2. Pohl O, et al. Br J Clin Pharmacol. 2018 Apr 30. doi: 10.1111/bcp.13622.

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