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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Chitinase-OAT-870
OAT-870

Chemical Structure : OAT-870

CAS No.: 2088453-18-1

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OAT-870 (OAT 870)

货号: PC-21913Not For Human Use, Lab Use Only.

OAT-870 is a potent dual AMCase and CHIT1 inhibitor with IC50 of 48/74 nM (human/ mouse CHIT1) and 22/30 nM (h/mAMCase).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

OAT-870 is a potent dual AMCase and CHIT1 inhibitor with IC50 of 48/74 nM (human/ mouse CHIT1) and 22/30 nM (h/mAMCase).
OAT-870 displays good in vitro activity for both human and murine chitinases.
OAT-870 exhibits significant anti-inflammatory effect in HDM-induced airway inflammation model in mice.

物理化学性质&存储条件

分子量 376.89
分子式 C18H25ClN6O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-5-(4-(3-(4-chlorobenzyl)morpholino)piperidin-1-yl)-1H-1,2,4-triazol-3-amine

参考文献

1. Marzena Mazur, et al. Int J Mol Sci. 2021 Jul; 22(13): 6966.

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