O-1602 |CAS:317321-41-8 Probechem Biochemicals

Chemical Structure : O-1602

CAS No.: 317321-41-8

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O-1602 (O1602)

货号: PC-35196Not For Human Use, Lab Use Only.

O-1602 (O1602) is an atypical cannabinoid, potent and selective agonist of GPR55 cannabinoid receptor with EC50 of 13 nM, shows no significant activity for CB1 and CB2 receptors (EC50>30 uM).

规格	价格	库存
10 mg	￥1980	In stock
25 mg	￥3280	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

O-1602 (O1602) is an atypical cannabinoid, potent and selective agonist of GPR55 cannabinoid receptor with EC50 of 13 nM, shows no significant activity for CB1 and CB2 receptors (EC50>30 uM).
O-1602 stimulates GPR55-dependent GTPgammaS activity with EC50 of <2 nM.
O-1602 inhibits mouse osteoclast formation in vitro, stimulates mouse and human osteoclast polarization and resorption in vitro and caused activation of Rho and ERK1/2, affects bone mass in vivo.
O-1602 protects against experimental colitis and inhibits neutrophil recruitment.

物理化学性质&存储条件

分子量	258.36
分子式	C17H22O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-Methyl-4-[(1R,6R)-3-methyl-6-(1-cyclohexen-1-yl]-1,3-benzenediol

参考文献

1. Johns DG, et al. Br J Pharmacol. 2007 Nov;152(5):825-31.

2. Whyte LS, et al. Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16511-6.

3. Schuelert N, et al. Neurosci Lett. 2011 Aug 1;500(1):72-6.

4. Schicho R, et al. Inflamm Bowel Dis. 2011 Aug;17(8):1651-64.

O-1602 (O1602)

生物&药学活性

物理化学性质&存储条件

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O-1602 (O1602)

生物&药学活性

物理化学性质&存储条件

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