Nucleozin

Chemical Structure : Nucleozin

CAS No.: 341001-38-5

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货号: PC-45819Not For Human Use, Lab Use Only.

Nucleozin is a small-molecule influenza A nucleoprotein (NP) inhibitor that triggers the aggregation of NP and inhibits its nuclear accumulation.

规格	价格	库存
5 mg	￥480	In stock
10 mg	￥780	In stock
25 mg	￥1280	In stock
50 mg	￥2180	In stock
100 mg		Get quote

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生物&药学活性

Nucleozin is a small-molecule influenza A nucleoprotein (NP) inhibitor that triggers the aggregation of NP and inhibits its nuclear accumulation.
Nucleozin inhibits infection of MDCK cells by viruses influenza A/WSN/33, H3N2 (clinical isolate) and Vietnam/1194/04 (H5N1) with EC50 of 0.069 uM, 0.16 uM and 0.33 uM in PRA, respectively.
Nucleozin protects mice challenged with lethal doses of avian influenza A H5N1.
Nucleozin also targets cytoplasmic trafficking of viral ribonucleoprotein-Rab11 complexes in influenza A virus infection.

物理化学性质&存储条件

分子量	426.853
分子式	C21H19ClN4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 28.66 mg/mL (Need ultrasonic)
Chemical Name/SMILES	Methanone, [4-(2-chloro-4-nitrophenyl)-1-piperazinyl](5-methyl-3-phenyl-4-isoxazolyl)-

参考文献

1. Kao RY, et al. Nat Biotechnol. 2010 Jun;28(6):600-5.

2. Amorim MJ, et al. J Virol. 2013 Apr;87(8):4694-703.

3. Su CY, et al. Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19151-6.

Nucleozin

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物理化学性质&存储条件

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Nucleozin

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