NuP-3 | MAPK13 inhibitor | Probechem Biochemicals

Chemical Structure : NuP-3

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NuP-3 (MAPK13-14 inhibitor NuP-3)

货号: PC-20899Not For Human Use, Lab Use Only.

NuP-3 is a potent, selective MAPK13 and MAPK14 inhibitor with IC50 of 7 and 14 nM, respectively.

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生物&药学活性

NuP-3 is a potent, selective MAPK13 and MAPK14 inhibitor with IC50 of 7 and 14 nM, respectively.
NuP-3 treatment markedly inhibited MUC5AC and CLCA1 induction in hTECs cultured under air-liquid interface conditions with IL-13 stimulation, but not the MAPK14 inhibitor NuP-43 (BIRB-796, Cat. PC-42520).
NuP-3 demonstrated similarly effective blockade of IL-13-stimulated MUC5AC and CLCA1 mRNA expression, without evidence of cell toxicity.
NuP-3 treatment effectively attenuates respiratory inflammation and mucus production in new minipig models of airway disease after type-2 cytokine challenge or respiratory viral infection.
NuP-3 also down-regulates biomarkers linked to basal-epithelial stem cell activation as an upstream site for target engagement.

物理化学性质&存储条件

分子量	470.93
分子式	C24H24ClFN4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(4-(3-(5-(tert-butyl)-2-chlorophenyl)ureido)-3-fluorophenoxy)pyridin-2-yl)acetamide

参考文献

1. Shamus P Keeler, et al. bioRxiv. 2023 May 27;2023.05.26.542451.

NuP-3 (MAPK13-14 inhibitor NuP-3)

生物&药学活性

物理化学性质&存储条件

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NuP-3 (MAPK13-14 inhibitor NuP-3)

生物&药学活性

物理化学性质&存储条件

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