Nrf2 activator 16 |CAS:321694-20-6 Probechem Biochemicals

Chemical Structure : Nrf2 activator 16

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Nrf2 activator 16 (Keap1-Nrf2 inhibitor 16)

货号: PC-62795Not For Human Use, Lab Use Only.

Nrf2 activator 16 is a potent Keap1-Nrf2 and Keap1-p-p62 protein-protein interaction inhibitor with IC50 of 0.91 uM and 1.8 uM respectively.

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生物&药学活性

Nrf2 activator 16 is a potent Keap1-Nrf2 and Keap1-p-p62 protein-protein interaction inhibitor with IC50 of 0.91 uM and 1.8 uM respectively.
Nrf2 activator 16 upregulates Nrf2 response genes measured by a luciferase cell reporter assay.

物理化学性质&存储条件

分子量	498.568
分子式	C24H22N2O6S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N,N'-(naphthalene-1,4-diyl)bis(4-methoxybenzenesulfonamide)

参考文献

1. Saito T, et al. Nat Commun. 2016 Jun 27;7:12030.

2. Yasuda D, et al. Bioorg Med Chem Lett. 2016 Dec 15;26(24):5956-5959.

3. Marcotte D, et al. Bioorg Med Chem. 2013 Jul 15;21(14):4011-9.

Nrf2 activator 16 (Keap1-Nrf2 inhibitor 16)

生物&药学活性

物理化学性质&存储条件

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Nrf2 activator 16 (Keap1-Nrf2 inhibitor 16)

生物&药学活性

物理化学性质&存储条件

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