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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-Notum-Notum inhibitor 4d
Notum inhibitor 4d

Chemical Structure : Notum inhibitor 4d

CAS No.: 1113111-36-6

Notum inhibitor 4d

货号: PC-72822Not For Human Use, Lab Use Only.

Notum inhibitor 4d is a highly potent inhibitor of Notum with IC50 of <10 nM, restores Wnt/β-catenin signaling in cell-based models.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Notum inhibitor 4d is a highly potent inhibitor of Notum with IC50 of <10 nM, restores Wnt/β-catenin signaling in cell-based models.
    Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity.

    物理化学性质&存储条件

    分子量 258.299
    分子式 C12H10N4OS
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    6-[(4-Methylphenyl)thio]-1,2,4-triazolo[4,3-b]pyridazin-3(2H)-one

    参考文献

    1. Steadman D, et al. J Med Chem. 2022 Jan 13;65(1):562-578.

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