Notum inhibitor 23dd

Chemical Structure : Notum inhibitor 23dd

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货号: PC-72823Not For Human Use, Lab Use Only.

Notum inhibitor 23dd is a potent, brain-penetrant and orally active inhibitor of Notum carboxylesterase activity with IC50 of 18 nM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Notum inhibitor 23dd is a potent, brain-penetrant and orally active inhibitor of Notum carboxylesterase activity with IC50 of 18 nM.
Notum inhibitor 23dd demonstrated good plasma exposure and partial blood–brain barrier penetration after oral administration in mouse.
Notum inhibitor 23dd is a new chemical tool for exploring the role of Notum-mediated regulation of Wnt signaling.

物理化学性质&存储条件

分子量	264.588
分子式	C9H4ClF3N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(4-chloro-3-(trifluoromethyl)phenyl)-1,3,4-oxadiazol-2(3H)-one

参考文献

1. Mahy W, et al. J Med Chem. 2020 Nov 12;63(21):12942-12956.