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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Lipoxygenase-Nordihydroguaiaretic acid
Nordihydroguaiaretic acid

Chemical Structure : Nordihydroguaiaretic acid

CAS No.: 500-38-9

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Nordihydroguaiaretic acid (NDGA)

货号: PC-24005Not For Human Use, Lab Use Only.

Nordihydroguaiaretic acid (NDGA) is a 5-lipoxygenase (5LOX) (IC50=8 μM) and tyrosine kinase inhibitor, also suppresses NOD-like receptor family pyrin domain containing 3 (Nlrp3) inflammasome activation and subsequent hepatic pyroptosis, inhibit ferroptosis in nucleus pulposus cells (NPCs).

规格 价格 库存 数量
50 mg ￥380 In stock
100 mg ￥580 In stock
500 mg ￥980 In stock
1 g Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Nordihydroguaiaretic acid (NDGA) is a 5-lipoxygenase (5LOX) (IC50=8 μM) and tyrosine kinase inhibitor, also suppresses NOD-like receptor family pyrin domain containing 3 (Nlrp3) inflammasome activation and subsequent hepatic pyroptosis, inhibit ferroptosis in nucleus pulposus cells (NPCs).

物理化学性质&存储条件

分子量 302.37
分子式 C18H22O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4,4'-(2,3-Dimethylbutane-1,4-diyl)bis(benzene-1,2-diol)

参考文献

1. Zhang Y, et al. Int Immunopharmacol. 2024 Dec 25;143(Pt 3):113590.

2. Zhu S, et al. J Hepatol. 2025 Jan 22:S0168-8278(25)00014-5.

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