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首页-小分子抑制剂&激动剂-Others-Other Targets-Norathyriol
Norathyriol

Chemical Structure : Norathyriol

CAS No.: 3542-72-1

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Norathyriol (Mangiferitin)

货号: PC-23907Not For Human Use, Lab Use Only.

Norathyriol (Mangiferitin) is a natural metabolite of Mangifera, inhibits α-glucosidase in a noncompetitive manner with IC50 of 3.12 uM, also inhibits inhibits PPARα, PPARβ, and PPARγ with IC50 of 90-100 uM, is also an effective inhibitor that targets the MEG pocket on the circPETH-147aa surface.

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5 mg ￥1980 In stock
10 mg ￥2980 In stock
25 mg ￥4980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Norathyriol (Mangiferitin) is a natural metabolite of Mangifera, inhibits α-glucosidase in a noncompetitive manner with IC50 of 3.12 uM, also inhibits inhibits PPARα, PPARβ, and PPARγ with IC50 of 90-100 uM, is also an effective inhibitor that targets the MEG pocket on the circPETH-147aa surface.
Norathyriol reverses circPETH-147aa-facilitated acquisition of metabolic and metastatic phenotypes by HCC cells, increases anti-PD1 efficacy, and enhances cytotoxic CD8+ T-cell function.
Norathyriol (1-25 µM) inhibits growth by inducing cell cycle arrest in JB6 P+ cells. Norathyriol inhibits JB6 cell growth by inducing G2-M arrest.

物理化学性质&存储条件

分子量 260.20
分子式 C13H8O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1,3,6,7-Tetrahydroxy-9H-xanthen-9-one

参考文献

1. Lan T, et al. Nat Commun. 2025 Jan 2;16(1):333.

2. Zhi-Long Shi, et al. Biochem Res Int. 2017;2017:1206015.

3. Ashley S Wilkinson, et al. J Agric Food Chem. 2008 May 14;56(9):3037-42.

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