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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-TRP Channel-Nonivamide
Nonivamide

Chemical Structure : Nonivamide

CAS No.: 2444-46-4

Nonivamide (Pseudocapsaicin;Pelargonic acid vanillylamide;Nonanoic acid vanillylamide)

货号: PC-45355Not For Human Use, Lab Use Only.

Nonivamide is a capsaicin analog that acts as an agonist of TRPV1 channel.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Nonivamide is a capsaicin analog that acts as an agonist of TRPV1 channel.
Nonivamide causes calcium release from the ER and alters the transcription of GADD153, GADD45alpha, GRP78/BiP, ATF3, CCND1, and CCNG2 in human bronchial epithelial and alveolar cells.
Nonivamide stimulates the Ca(2+)-dependent release of serotonin and dopamine in SH-SY5Y cells at 1 uM.
Nonivamide also enhances miRNA let-7d expression and decreases adipogenesis PPARγ expression in 3T3-L1 cells.

物理化学性质&存储条件

分子量 293.4012
分子式 C17H27NO3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Nonanamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]-

参考文献

1. Rohm B, et al. Mol Nutr Food Res. 2013 Nov;57(11):2008-18.

2. Thomas KC, et al. J Pharmacol Exp Ther. 2007 Jun;321(3):830-8.

3. Rohm B, et al. J Cell Biochem. 2015 Jun;116(6):1153-63.

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