Nobiletin |CAS:478-01-3 Probechem Biochemicals

Chemical Structure : Nobiletin

CAS No.: 478-01-3

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Nobiletin

货号: PC-63473Not For Human Use, Lab Use Only.

Nobiletin is an O-methylated flavone that has the activity to rescue bulbectomy-induced memory impairment, also is a clock modulator that targets RORα/γ.

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25 mg	￥780	In stock
50 mg	￥1380	In stock
100 mg	￥2180	In stock
250 mg		Get quote
1 g		Get quote

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生物&药学活性

Nobiletin is an O-methylated flavone that has the activity to rescue bulbectomy-induced memory impairment, also is a clock modulator that targets RORα/γ.
Nobiletin induces neurite outgrowth of PC12D cells, causes a concentration-dependent enhancement of Erk/MAP kinase phosphorylation and a sustained increment of phosphorylation of MEK and Erk/MAP kinase.
Nobiletin also preferentially inhibits Ca2+/CaM-dependent phosphodiesterase in vitro.
Nobiletin enhances the clock and concordantly renders protection against metabolic syndrome in a Clock gene-dependent manner, enhances RORα/γ transcriptional activity via direct binding to RORα/γ.

物理化学性质&存储条件

分子量	402.399
分子式	C21H22O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3',4',5,6,7,8-Hexamethoxyflavone

参考文献

1. Nagase H, et al. Biochemistry. 2005 Oct 25;44(42):13683-91.

2. He B, et al. Cell Metab. 2016 Apr 12;23(4):610-21.

3. Nakajima A, et al. J Pharmacol Sci. 2007 Sep;105(1):122-6.

Nobiletin

生物&药学活性

物理化学性质&存储条件

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Nobiletin

生物&药学活性

物理化学性质&存储条件

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