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Nizubaglustat

Chemical Structure : Nizubaglustat

CAS No.: 1633666-49-5

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Nizubaglustat (AZ-3102, AZ3102)

货号: PC-20061Not For Human Use, Lab Use Only.

Nizubaglustat (AZ-3102) is a potent, selective inhibitor of glucosylceramide synthase (GCS) with IC50 of 25 nM, inhibits acid glucosylceramidase (GBA1) and neutral glucosylceramidase (GBA2) with IC50 of 200 and 0.08 nM, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Nizubaglustat (AZ-3102) is a potent, selective inhibitor of glucosylceramide synthase (GCS) with IC50 of 25 nM, inhibits acid glucosylceramidase (GBA1) and neutral glucosylceramidase (GBA2) with IC50 of 200 and 0.08 nM, respectively.

    物理化学性质&存储条件

    分子量 433.52
    分子式 C24H32FNO5
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (2S,3R,4R,5S)-1-(5-((2-fluoro-[1,1'-biphenyl]-4-yl)methoxy)pentyl)-2-(hydroxymethyl)piperidine-3,4,5-triol

    参考文献

    1. Amar T Ghisaidoobe, et al. J Med Chem. 2014 Nov 13;57(21):9096-104.

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