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首页-小分子抑制剂&激动剂-Apoptosis-Caspase-Nitrosonisoldipine
Nitrosonisoldipine

Chemical Structure : Nitrosonisoldipine

CAS No.: 87375-91-5

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Nitrosonisoldipine (Dehydronitrosonisoldipine)

货号: PC-26191Not For Human Use, Lab Use Only.

Nitrosonisoldipine is a photodegradation product of calcium channel inhibitor nisoldipine, is a selective inhibitor of inflammatory caspases, inhibits noncanonical pyroptosis mediated by caspase-11 or caspase-4 and canonical pyroptosis mediated by caspase-1.

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5 mg ￥1380 In stock
10 mg ￥2180 In stock
25 mg ￥3780 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Nitrosonisoldipine is a photodegradation product of calcium channel inhibitor nisoldipine, is a selective inhibitor of inflammatory caspases, inhibits noncanonical pyroptosis mediated by caspase-11 or caspase-4 and canonical pyroptosis mediated by caspase-1.
Nitrosonisoldipine inhibits noncanonical pyroptosis in iBMDMs。
Nitrosonisoldipine blocks caspase-4/-11 activation in noncanonical pyroptosis.
Nitrosonisoldipine blocks caspase-1 activation in canonical pyroptosis.
Nitrosonisoldipine does not affect apoptosis.
Nitrosonisoldipine directly and irreversibly inhibits the enzyme activities of inflammatory caspases.
Nitrosonisoldipine (4.44, 14.8, and 44.4 mg/kg) is protective in LPS- and polymicrobe-induced sepsis in C57BL/6 mice.

物理化学性质&存储条件

分子量 370.41
分子式 C20H22N2O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-Isobutyl 5-methyl 2,6-dimethyl-4-(2-nitrosophenyl)pyridine-3,5-dicarboxylate

参考文献

1. Qianyue Chen, et al. Eur J Immunol. 2021 May;51(5):1234-1245.

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