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首页-小分子抑制剂&激动剂-Tyrosine Kinase-Bcr-Abl-Nispomeben
Nispomeben

Chemical Structure : Nispomeben

CAS No.: 1443133-41-2

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Nispomeben (NRD.E1, NRD135S.E1)

货号: PC-24969Not For Human Use, Lab Use Only.

Nispomeben (NRD.E1, NRD135S.E1) is a nonopioid, orally available small molecule with potential for painful diabetic peripheral neuropathy (PDPN), NRD.E1 is hypothesised to be through modulation of the phosphorylation of Lyn tyrosine kinase.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Nispomeben (NRD.E1, NRD135S.E1) is a nonopioid, orally available small molecule with potential for painful diabetic peripheral neuropathy (PDPN), NRD.E1 is hypothesised to be through modulation of the phosphorylation of Lyn tyrosine kinase.
Nispomeben (NRD.E1, NRD135S.E1) has shown dose‐dependent anti‐nociceptive effects in several rodent models for both acute and chronic pain, including streptozotocin‐induced diabetic neuropathy, Chung's spinal nerve ligation, tail flick, hot plate and formalin injection.
Nispomeben (NRD.E1, NRD135S.E1) is hypothesised to be through modulation of the phosphorylation of Lyn tyrosine kinase, a critical step in the mediation of nerve injury‐induced P2X4 receptor upregulation in neuropathic pain.
Nispomeben (NRD.E1, NRD135S.E1) does not appear to act directly through any of the mechanisms, receptors, enzymes or channels known to be associated with pain and abuse‐liability, including opioid receptors.

物理化学性质&存储条件

分子量 357.45
分子式 C21H27NO4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-((S)-1-(4-hydroxyphenyl)-3-((S)-2-hydroxypropoxy)propan-2-yl)-3-phenylpropanamide

参考文献

1. Patent WO2013084238 A1.

2. Tiecke E, et al. Clin Pharmacol Drug Dev. 2022 Sep;11(9):1012-1027.

3. Tiecke E, et al. Eur J Pain. 2022 Sep;26(8):1665-1678.

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