Niraxostat (Y-700) | Xanthine oxidase inhibitor | Probechem Biochemicals

Chemical Structure : Niraxostat

CAS No.: 206884-98-2

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Niraxostat (Y-700, Y700)

货号: PC-20359Not For Human Use, Lab Use Only.

Niraxostat (Y-700) is a potent, long-lasting, orally effective xanthine oxidase (XO) inhibitor with IC50 of 5.8 nM, exhibits potent and long-lasting hypouricemic effect in rat model of hyperuricemia.

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10 mg	￥3580	In stock
25 mg	￥5880	In stock
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生物&药学活性

Niraxostat (Y-700) is a potent, long-lasting, orally effective xanthine oxidase (XO) inhibitor with IC50 of 5.8 nM, exhibits potent and long-lasting hypouricemic effect in rat model of hyperuricemia.
Niraxostat (Y-700) binds tightly both to the active sulfo-form and to the inactive desulfo-form of the enzyme with K(d) values of 0.9 and 2.8 nM, respectively.
Y-700 (1-10 mg/kg, oral) dose dependently lowered plasma urate levels in oxonate-treated rats.
Y-700 (0.3-3 mg/kg) dose dependently reduced the urinary excretion of urate and allantoin in normal rats.

物理化学性质&存储条件

分子量	299.33
分子式	C16H17N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(3-cyano-4-neopentyloxyphenyl)pyrazole-4-carboxylic acid

参考文献

1. S Ishibuchi, et al. Bioorg Med Chem Lett. 2001 Apr 9;11(7):879-82.

2. Fukunari A, et al. J Pharmacol Exp Ther. 2004 Nov;311(2):519-28.

Niraxostat (Y-700, Y700)

生物&药学活性

物理化学性质&存储条件

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Niraxostat (Y-700, Y700)

生物&药学活性

物理化学性质&存储条件

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