Niraparib tosylate (MK-4827) | PARP1/2 inhibitor | Probechem Biochemicals

Chemical Structure : Niraparib tosylate

CAS No.: 1038915-73-9

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Niraparib tosylate (MK-4827 tosylate, MK4827 tosylate)

货号: PC-42683Not For Human Use, Lab Use Only.

Niraparib tosylate (MK-4827) is a highly potent PARP inhibitor with IC50 of 3.8 nM/2.1 nM for PARP1/PARP2.

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1380	In stock
50 mg	￥2180	In stock
100 mg	￥3580	In stock
250 mg		Get quote

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生物&药学活性

Niraparib tosylate (MK-4827) is a highly potent PARP inhibitor with IC50 of 3.8 nM/2.1 nM for PARP1/PARP2.
Niraparib inhibits PARP activity with EC50=4 nM in a whole cell assay, and inhibits proliferation of cancer cells with mutant BRCA-1 and BRCA-2 with CC50 in the 10−100 nM range.
Niraparib is well tolerated in vivo and demonstrates efficacy as a single agent in a xenograft model of BRCA-1 deficient cancer.

物理化学性质&存储条件

分子量	492.5899
分子式	C26H28N4O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 490 mg/mL
Chemical Name/SMILES	2H-Indazole-7-carboxamide, 2-[4-(3S)-3-piperidinylphenyl]-, 4-methylbenzenesulfonate (1:1)

参考文献

1. Jones P, et al. J Med Chem. 2009 Nov 26;52(22):7170-85.

2. Bridges KA, et al. Oncotarget. 2014 Jul 15;5(13):5076-86.

3. Mirza MR, et al. N Engl J Med. 2016 Dec 1;375(22):2154-2164.

Niraparib tosylate (MK-4827 tosylate, MK4827 tosylate)

生物&药学活性

物理化学性质&存储条件

参考文献

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Niraparib tosylate (MK-4827 tosylate, MK4827 tosylate)

生物&药学活性

物理化学性质&存储条件

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