Nintedanib esylate |CAS:656247-18-6 Probechem Biochemicals

Chemical Structure : Nintedanib esylate

CAS No.: 656247-18-6

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Nintedanib esylate (BIBF1120 esylate, BIBF-1120 esylate)

货号: PC-42813Not For Human Use, Lab Use Only.

Nintedanib esylate (BIBF1120 esylate) is a potent triple angiokinase (VEGFR/PDGFR/FGFR) inhibitor with IC50 of 5/38/18/104/5 nM for VEGFR-2/FGFR-1/PDGFRα/VEGFR-1/VEGFR-3, respectively.

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50 mg	￥880	In stock
100 mg	￥1280	In stock
500 mg		Get quote
1 g		Get quote

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生物&药学活性

Nintedanib esylate (BIBF1120 esylate) is a potent triple angiokinase (VEGFR/PDGFR/FGFR) inhibitor with IC50 of 5/38/18/104/5 nM for VEGFR-2/FGFR-1/PDGFRα/VEGFR-1/VEGFR-3, respectively.
Nintedanib inhibits MAPK and Akt signaling pathways, show inhibition of cell proliferation (EC50=10-80 nM).
Nintedanib is fully efficacious in xenograft models and orally active.

物理化学性质&存储条件

分子量	649.7571
分子式	C33H39N5O7S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Indole-6-carboxylic acid, 2,3-dihydro-3-[[[4-[methyl[2-(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-, methyl ester, (3Z)-, ethanesulfonate (1:1)

参考文献

1. Roth GJ, et al. J Med Chem. 2009 Jul 23;52(14):4466-80.

2. Hilberg F, et al. Cancer Res. 2008 Jun 15;68(12):4774-82.

3. Kudo K, et al. Clin Cancer Res. 2011 Mar 15;17(6):1373-81.

Nintedanib esylate (BIBF1120 esylate, BIBF-1120 esylate)

生物&药学活性

物理化学性质&存储条件

参考文献

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Nintedanib esylate (BIBF1120 esylate, BIBF-1120 esylate)

生物&药学活性

物理化学性质&存储条件

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