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Ningetinib

Chemical Structure : Ningetinib

CAS No.: 1394820-69-9

Ningetinib (CT053PTSA)

货号: PC-21636Not For Human Use, Lab Use Only.

Ningetinib (CT053PTSA) is a potent, orally bioavailable multikinase inhibitor against c-Met, VEGFR2 as well as Axl, Mer, and FLT3, shows IC50s of 6.7, 1.9 and < 1.0 nM against c-Met, VEGFR-2 and Axl in cell-based assays.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Ningetinib (CT053PTSA) is a potent, orally bioavailable multikinase inhibitor against c-Met, VEGFR2 as well as Axl, Mer, and FLT3, shows IC50s of 6.7, 1.9 and < 1.0 nM against c-Met, VEGFR-2 and Axl in cell-based assays.
Ningetinib (CT053PTSA) inhibits HGF and VEGF-stimulated HUVEC proliferation and microvascular angiogenesis in rat aortic rings with IC50 values of 8.6 and 6.3 nM, respectively.
Ningetinib (CT053PTSA) (3mg/kg, oral) potently inhibits the phosphorylation of c-Met and its downstream signaling kinases AKT and ERK1/2 in tumor tissues of U87MG tumor-bearing nude mice.
Ningetinib (CT053PTSA) (20 mg/kg/day) potently inhibits tumor growth orthotopic U87MG human glioblastoma xenograft model.

物理化学性质&存储条件

分子量 556.59
分子式 C31H29FN4O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(3-fluoro-4-((7-(2-hydroxy-2-methylpropoxy)quinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide

参考文献

1. Zhao S, et al. Lung Cancer. 2024 Jan 3;188:107468.

2. Ning Xi, et al. Cancer Res (2014) 74 (19_Supplement): 1755.

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