Nigratine | RIPK1 inhibitor | Probechem Biochemicals

Chemical Structure : Nigratine

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Nigratine (6E11)

货号: PC-72528Not For Human Use, Lab Use Only.

Nigratine (6E11) is a highly specific, non-ATP competitive inhibitor of RIPK1 kinase (IC50=1.6 uM), inhibits necroptosis and ferroptosis.

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250 mg		Get quote

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生物&药学活性

Nigratine (6E11) is a highly specific, non-ATP competitive inhibitor of RIPK1 kinase (IC50=1.6 uM), inhibits necroptosis and ferroptosis.
Nigratine inhibits necroptotic cell-death induced by TNF-α in Jurkat-Fadd def cells with IC50 of 4.6 uM.
Nigratine is significantly more potent than the specific RIPK1 necroptosis inhibitor, Nec-1s.
Nigratine (50 uM) strongly inhibits the ferroptotic cell death induced by excess of glutamate, erastin, and RSL3, in both murine HT22 and human SH-SY5Y cell lines, protects SH-SY5Y human neuroblastoma cell line from cell death triggered by both class I and II-inducers of ferroptosis.
Nigratine protects porcine kidney epithelial LLC-PK1 cell line from lipid peroxidation and cell death triggered by RSL3.
Nigratine protects human bronchial organoids from necroptosis and ferroptosis.

物理化学性质&存储条件

分子量	392.407
分子式	C23H20O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-(benzyloxy)phenyl)-2,5-dihydroxy-7-methoxychroman-4-one

参考文献

1. Claire Delehouzé, et al. Sci Rep. 2022 Mar 24;12(1):5118.

Nigratine (6E11)

生物&药学活性

物理化学性质&存储条件

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Nigratine (6E11)

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物理化学性质&存储条件

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