Nigericin sodium | Potassium ionophore, NLRP3 agonist

Chemical Structure : Nigericin sodium

CAS No.: 28643-80-3

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Nigericin sodium (Sodium Nigericin, NSC 292567)

货号: PC-42123Not For Human Use, Lab Use Only.

Nigericin sodium (NSC 292567) is an ionophore antibiotic derived from S. hygroscopicus that acts as a potassium ionophore promoting K+/H+ exchange across mitochondrial membranes.

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10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

Nigericin sodium (NSC 292567) is an ionophore antibiotic derived from S. hygroscopicus that acts as a potassium ionophore promoting K+/H+ exchange across mitochondrial membranes.
Nigericin sodium is a research tool to disrupt intracellular H+ and K+ concentration, thus altering pH, membrane potential, and cell volum。
Nigericin sodium inhibits the Golgi functions in Eukaryotic cells.
Nigericin sodium is the canonical NLRP3 inflammasome agonist.

物理化学性质&存储条件

分子量	746.9432
分子式	C40H67NaO11
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in ethanol; DMSO: < 0.3 mg/mL; H2O: < 0.3 mg/mL
Chemical Name/SMILES	Nigericin, sodium salt (1:1)

参考文献

1. Gray MA, et al. Eur J Biochem. 1983 Sep 15;135(2):299-302.

2. Zotova L, et al. J Biol Chem. 2010 May 7;285(19):14399-414.

3. Tartakoff AM, et al. J Exp Med. 1977 Nov 1;146(5):1332-45.

4. Boesch M, et al. Stem Cells Transl Med. 2015 Sep;4(9):1028-32.

Nigericin sodium (Sodium Nigericin, NSC 292567)

生物&药学活性

物理化学性质&存储条件

参考文献

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Nigericin sodium (Sodium Nigericin, NSC 292567)

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物理化学性质&存储条件

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