Nicotinamide riboside

Chemical Structure : Nicotinamide riboside

CAS No.: 23111-00-4

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货号: PC-23870Not For Human Use, Lab Use Only.

规格	价格	库存
50 mg	￥280	In stock
100 mg	￥380	In stock
500 mg	￥880	In stock
1 g		Get quote

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生物&药学活性

Nicotinamide riboside (NR) is an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3, promotes peroxisome proliferator-activated receptor-γ coactivator 1 (PGC)-1α expression in the brain.
Nicotinamide riboside supplementation in mammalian cells and mouse tissues increases NAD(+) levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high-fat diet-induced metabolic abnormalities.
Nicotinamide riboside regulates β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models.

物理化学性质&存储条件

分子量	290.70
分子式	C11H15ClN2O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-Carbamoyl-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium chloride

参考文献

1. Cantó C, et al. Cell Metab. 2012 Jun 6;15(6):838-47.

2. Bing Gong, et al. Neurobiol Aging. 2013 Jun;34(6):1581-8.