Nezulcitinib (TD-0903)| pan JAK inhibitor | Probechem Biochemicals

Chemical Structure : Nezulcitinib

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Nezulcitinib (TD-0903, TD0903)

货号: PC-38381Not For Human Use, Lab Use Only.

Nezulcitinib (TD-0903) is a inhaled lung-selective pan-JAK inhibitor, targets all JAK isoforms (JAK1, JAK2, JAK3, TYK2), Nezulcitinib is under development for treatment of acute lung injury associated with COVID-19.

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生物&药学活性

Nezulcitinib (TD-0903) is a inhaled lung-selective pan-JAK inhibitor, targets all JAK isoforms (JAK1, JAK2, JAK3, TYK2), Nezulcitinib is under development for treatment of acute lung injury associated with COVID-19.

物理化学性质&存储条件

分子量	527.673
分子式	C30H37N7O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-(3-(dimethylamino)azetidin-1-yl)(2-(6-(2-ethyl-4-hydroxyphenyl)-1H-indazol-3-yl)-5-isopropyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-6-yl)methanone

参考文献

1. Singh D, et al. Eur Respir J. 2021 Oct 14;58(4):2100673.

2. Spinelli, F. R., Conti, F. & Gadina, M. HiJAKing SARS-CoV-2? The potential role of JAK inhibitors in the management of COVID-19. Sci. Immunol. 5, eabc5367 (2020).

3. Pfeifer ND, et al. Clin Transl Sci. 2021 Nov;14(6):2556-2565.

Nezulcitinib (TD-0903, TD0903)

生物&药学活性

物理化学性质&存储条件

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Nezulcitinib (TD-0903, TD0903)

生物&药学活性

物理化学性质&存储条件

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