Neurounina-1 | NCX activator | Probechem Biochemicals

Chemical Structure : Neurounina-1

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Neurounina-1 (Neurounina 1)

货号: PC-73273Not For Human Use, Lab Use Only.

Neurounina-1 is a small molecule Na+/Ca2+ exchanger (NCX) activator, stimulates NCX1 and NCX2 activities with EC50 of 1.1-2.7 nM, does not affect NCX3 activity.

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生物&药学活性

Neurounina-1 is a small molecule Na+/Ca2+ exchanger (NCX) activator, stimulates NCX1 and NCX2 activities with EC50 of 1.1-2.7 nM, does not affect NCX3 activity.
Neurounina-1 (10 nM) reduced cell death of primary cortical neurons exposed to oxygen-glucose deprivation followed by reoxygenation, also reduced γ-aminobutyric acid (GABA) release, enhanced GABA(A) currents, and inhibited both glutamate release and N-methyl-d-aspartate receptors in vitro.
Neurounina-1 effectively protects against stroke damage in vivo.

物理化学性质&存储条件

分子量	364.405
分子式	C20H20N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-nitro-5-phenyl-1-(pyrrolidin-1-ylmethyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one

参考文献

1. Molinaro P, et al. Mol Pharmacol. 2013 Jan;83(1):142-56.

2. Severino B, et al. Front Pharmacol. 2019 Apr 25;10:432.

3. Magli E, et al. J Med Chem. 2021 Dec 23;64(24):17901-17919.

Neurounina-1 (Neurounina 1)

生物&药学活性

物理化学性质&存储条件

参考文献

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Neurounina-1 (Neurounina 1)

生物&药学活性

物理化学性质&存储条件

参考文献

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