Netazepide |CAS:155488-25-8 Probechem Biochemicals

Chemical Structure : Netazepide

CAS No.: 155488-25-8

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Netazepide (YF476;YF-476;Sograzepide)

货号: PC-60082Not For Human Use, Lab Use Only.

Netazepide (YF476, Sograzepide) is a potent, selective and orally active gastrin/CCK-2 antagonist with IC50 of 0.1 nM.

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10 mg	￥2580	In stock
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生物&药学活性

Netazepide (YF476, Sograzepide) is a potent, selective and orally active gastrin/CCK-2 antagonist with IC50 of 0.1 nM.
Netazepide (YF476, Sograzepide) displays >5,000-fold selectivity over CCK-1 receptors.
Netazepide (YF476, Sograzepide) inhibits pentagastrin-induced gastric acid secretion in anesthetized rats (ED50=87 nM/kg), and shows potential for the treatment of gastroesophageal reflux disease (GERD).
Netazepide (YF476, Sograzepide) also inhibits gastric neuroendocrine enterochromaffin-like (ECL) cell hyperplasia and gastric carcinoid tumor development.

物理化学性质&存储条件

分子量	498.587
分子式	C28H30N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-1-(1-(3,3-dimethyl-2-oxobutyl)-2-oxo-5-(pyridin-2-yl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-3-(3-(methylamino)phenyl)urea

参考文献

1. Semple G, et al. J Med Chem. 1997 Jan 31;40(3):331-41.

2. Takinami Y, et al. Aliment Pharmacol Ther. 1997 Feb;11(1):113-20.

3. Takemoto Y, et al. Arzneimittelforschung. 1998 Apr;48(4):403-7.

4. Kidd M, et al. Regul Pept. 2010 Jun 8;162(1-3):52-60.

Netazepide (YF476;YF-476;Sograzepide)

生物&药学活性

物理化学性质&存储条件

参考文献

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Netazepide (YF476;YF-476;Sograzepide)

生物&药学活性

物理化学性质&存储条件

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