Netarsudil | ROCK inhibitor | Probechem Biochemicals

Chemical Structure : Netarsudil

CAS No.: 1254032-66-0

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Netarsudil (AR-13324, AR13324)

货号: PC-62714Not For Human Use, Lab Use Only.

Netarsudil (AR-13324) is a potent, selective ROCK inhibitor with Ki of 4.2 nM for ROCK2.

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2 mg	￥1380	In stock
5 mg	￥2380	In stock
10 mg	￥3980	In stock
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生物&药学活性

Netarsudil (AR-13324) is a potent, selective ROCK inhibitor with Ki of 4.2 nM for ROCK2.
Netarsudil (AR-13324) is highly selective, 11 kinases are inhibited >90% in a panel of 422 kinases, only ROCK1 and ROCK2 (each 93% inhibition) and PKC (delta, 91%, and eta, 93% inhibition).
Netarsudil (AR-13324) exhibts improved bioavailability, demonstrates an effective and sustained IOP reduction for 24h after dosing.
Netarsudil (AR-13324) a novel ocular hypotensive agent for the treatment of glaucoma.

物理化学性质&存储条件

分子量	453.54
分子式	C28H27N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-4-(3-amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl 2,4-dimethylbenzoate

参考文献

1. Sturdivant JM, et al. Bioorg Med Chem Lett. 2016 May 15;26(10):2475-80.

2. Li G, et al. Eur J Pharmacol. 2016 Sep 15;787:20-31.

3. Lin CW, et al. J Ocul Pharmacol Ther. 2017 Jun 13. doi: 10.1089/jop.2017.0023.

Netarsudil (AR-13324, AR13324)

生物&药学活性

物理化学性质&存储条件

参考文献

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Netarsudil (AR-13324, AR13324)

生物&药学活性

物理化学性质&存储条件

参考文献

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