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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-PARP-Nesuparib
Nesuparib

Chemical Structure : Nesuparib

CAS No.: 2055357-64-5

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Nesuparib (JPI-547, NOV140201)

货号: PC-73432Not For Human Use, Lab Use Only.

Nesuparib (JPI-547, NOV140201) is a potent, oral, dual inhibitor of PARP 1/2 and Tankyrase 1/2, demonstrates anti-tumor activity in BRCA-deficient cancer.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Nesuparib (JPI-547, NOV140201) is a potent, oral, dual inhibitor of PARP 1/2 and Tankyrase 1/2, demonstrates anti-tumor activity in BRCA-deficient cancer.
Nesuparib (JPI-547, NOV140201) shows anti-tumor activity in BRCA-deficient xenograft models as a single-agent and in combination with chemotherapy and immune checkpoint inhibitors.

物理化学性质&存储条件

分子量 400.486
分子式 C23H24N6O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-Pyridinecarbonitrile, 6-[4-[(1,2,3,4,5,6-hexahydro-5-oxobenzo[h]-1,6-naphthyridin-8-yl)methyl]-1-piperazinyl]-

参考文献

1. Seock-Ah Im, et al. 2021 ASCO Annual Meeting I.

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