Nek2 inhibitor 3a |CAS: 2514949-36-9 Probechem Biochemicals

Chemical Structure : Nek2 inhibitor 3a

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Nek2 inhibitor 3a

货号: PC-61478Not For Human Use, Lab Use Only.

Nek2 inhibitor 3a is a potent, relatively selective Nek2 inhibitor with IC50 of 82.74 nM in cell-free assays.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

Nek2 inhibitor 3a is a potent, relatively selective Nek2 inhibitor with IC50 of 82.74 nM in cell-free assays.
Nek2 inhibitor 3a inhibits only 3 kinases (YSK4, FLT3-ITDD835V and FLT3-ITDF691L) against 97 kinases with >65% inhibition at 15 nM.
Nek2 inhibitor 3a blocks NEK2-EZH2 complex formation and inhibits tumor cell proliferation.
Nek2 inhibitor 3a efficiently attenuates GBM growth in mouse model and exhibits a synergistic effect with radiotherapy.

物理化学性质&存储条件

分子量	568.619
分子式	C28H27F3N6O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-5-(7-(1-(2-(dimethylamino)ethyl)-1H-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide

参考文献

1. Wang J, et al. J Clin Invest. 2017 Aug 1;127(8):3075-3089.