Nef-IN-B9 |CAS:1473404-51-1 Probechem Biochemicals

Chemical Structure : Nef-IN-B9

CAS No.: 1473404-51-1

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Nef-IN-B9 (Hck inhibitor B9)

货号: PC-62456Not For Human Use, Lab Use Only.

Nef-IN-B9 (Hck inhibitor B9) is a small molecule that blocks Nef-dependent Hck activity with IC50 of 2.8 uM, while the activity against Hck alone is >20 uM.

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10 mg	￥2580	In stock
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生物&药学活性

Nef-IN-B9 (Hck inhibitor B9) is a small molecule that blocks Nef-dependent Hck activity with IC50 of 2.8 uM, while the activity against Hck alone is >20 uM.
Nef-IN-B9 (Hck inhibitor B9) also showes weak activity against other Src-family members with IC50 of >20 uM for c-Src, Lck and Lyn.
Nef-IN-B9 (Hck inhibitor B9) blocks wild-type HIV-1 replication with IC50 of 100-300 nM, and blocks Nef-mediated SFK activation in HIV-infected cells.
Nef-IN-B9 (Hck inhibitor B9) binds directly to Nef with Kd of 1.79 nM.

物理化学性质&存储条件

分子量	402.813
分子式	C16H11ClN6O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-4-((3-chlorophenyl)diazenyl)-5-hydroxy-3-(4-nitrophenyl)-1H-pyrazole-1-carbothioamide

参考文献

1. Emert-Sedlak LA, et al. Chem Biol. 2013 Jan 24;20(1):82-91.

Nef-IN-B9 (Hck inhibitor B9)

生物&药学活性

物理化学性质&存储条件

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Nef-IN-B9 (Hck inhibitor B9)

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物理化学性质&存储条件

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