Necrox-5 methanesulfonate |CAS:1383718-29-3 Probechem Biochemicals

Chemical Structure : Necrox-5 methanesulfonate

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Necrox-5 methanesulfonate (Necrosis inhibitor 5)

货号: PC-62587Not For Human Use, Lab Use Only.

NecroX-5 is a novel necroptosis inhibitor that reduces mitochondrial oxidative stress, prevents hypoxia/reoxygenation injury by inhibiting the mitochondrial calcium uniporter.

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生物&药学活性

NecroX-5 is a novel necroptosis inhibitor that reduces mitochondrial oxidative stress, prevents hypoxia/reoxygenation injury by inhibiting the mitochondrial calcium uniporter; improves mitochondrial oxygen consumption, and suppresses mitochondrial Ca(2+) overload during reoxygenation in an in vitro rat heart HR model, reduces the ouabain- or histamine-induced increase in mitochondrial Ca(2+).

物理化学性质&存储条件

分子量	645.801
分子式	C27H39N3O9S3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-[(1,1-dioxido-4-thiomorpholinyl)methyl]-2-phenyl-N-[(tetrahydro-2H-pyran-4-yl)methyl]-1H-indol-7-amine, dimethanesulfonate

参考文献

1. Thu VT, et al. Cardiovasc Res. 2012 May 1;94(2):342-50.

2. Li X, et al. Allergy. 2016 Feb;71(2):198-209.

3. Park JH, et al. Int J Oncol. 2017 Jan;50(1):185-192.

4. Thu VT, et al. Korean J Physiol Pharmacol. 2016 Mar;20(2):201-11.

Necrox-5 methanesulfonate (Necrosis inhibitor 5)

生物&药学活性

物理化学性质&存储条件

参考文献

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Necrox-5 methanesulfonate (Necrosis inhibitor 5)

生物&药学活性

物理化学性质&存储条件

参考文献

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