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首页-小分子抑制剂&激动剂-Apoptosis-RIP kinase-Necrostatin-5
Necrostatin-5

Chemical Structure : Necrostatin-5

CAS No.: 337349-54-9

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Necrostatin-5 (Nec-5)

货号: PC-22668Not For Human Use, Lab Use Only.

Necrostatin-5 (Nec-5) is a potent, specific necroptosis inhibitor with EC50 of 240 nM in Jurkat cells, selectively and allosterically inhibits RIP1 kinase (RIPK-1).

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10 mg ￥780 In stock
25 mg ￥1280 In stock
50 mg ￥2180 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Necrostatin-5 (Nec-5) is a potent, specific necroptosis inhibitor with EC50 of 240 nM in Jurkat cells, selectively and allosterically inhibits RIP1 kinase (RIPK-1).

物理化学性质&存储条件

分子量 383.48
分子式 C19H17N3O2S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-((3-(4-Methoxyphenyl)-4-oxo-3,4,5,6,7,8-hexahydrobenzo[4,5]thieno[2,3-d]pyrimidin-2-yl)thio)acetonitrile

参考文献

1. Degterev A, et al. Nat Chem Biol. 2008 May;4(5):313-21.

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