Necrostatin-1 | Necroptosis inhibitor, RIPK1 inhibitor

Chemical Structure : Necrostatin-1

CAS No.: 4311-88-0

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Necrostatin-1 (Nec-1)

货号: PC-22667Not For Human Use, Lab Use Only.

规格	价格	库存
10 mg	￥680	In stock
25 mg	￥980	In stock
50 mg	￥1380	In stock
100 mg		Get quote

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生物&药学活性

Necrostatin-1 (Nec-1) is a potent, specific and BBB-permeable necroptosis inhibitor with EC50 of 490 nM in Jurkat cells, selectively and allosterically inhibits RIP1 kinase (RIPK-1) with EC50 of 182 nM.
Necrostatin-1 is a micromolar inhibitor of indolamine 2,3-deoxygenase (IDO) with EC50 = 11.4 μM in a cell-based assay.
Necrostatin-1 protects against glutamate-induced glutathione depletion and caspase-independent cell death in HT-22 cells.

物理化学性质&存储条件

分子量	259.33
分子式	C13H13N3OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-((1H-Indol-3-yl)methyl)-3-methyl-2-thioxoimidazolidin-4-one

参考文献

1. Degterev A, et al. Nat Chem Biol. 2005 Jul;1(2):112-9.

2. Xu X, et al. J Neurochem. 2007 Dec;103(5):2004-14.

3. Degterev A, et al. Nat Chem Biol. 2008 May;4(5):313-21.

Necrostatin-1 (Nec-1)

生物&药学活性

物理化学性质&存储条件

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Necrostatin-1 (Nec-1)

生物&药学活性

物理化学性质&存储条件

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