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首页-小分子抑制剂&激动剂-Apoptosis-RIP kinase-Nec-1s
Nec-1s

Chemical Structure : Nec-1s

CAS No.: 852391-15-2

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Nec-1s (7-Cl-O-Nec1, Necrostatin 1S, Necrostatin 2 racemate)

货号: PC-22669Not For Human Use, Lab Use Only.

Nec-1s (7-Cl-O-Nec-1) is an optimized derivative of Nec-1 and potent, specific necroptosis inhibitor with EC50 of 210 nM in Jurkat cells, exhibits the protection in an ischemic brain injury model, selectively inhibits RIPK1 and lacks activity against IDO.

规格 价格 库存 数量
5 mg ￥980 In stock
10 mg ￥1380 In stock
25 mg ￥2180 In stock
50 mg ￥3680 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Nec-1s (7-Cl-O-Nec-1) is an optimized derivative of Nec-1 and potent, specific necroptosis inhibitor with EC50 of 210 nM in Jurkat cells, exhibits the protection in an ischemic brain injury model, selectively inhibits RIPK1 and lacks activity against IDO.

物理化学性质&存储条件

分子量 277.71
分子式 C13H12ClN3O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-((7-Chloro-1H-indol-3-yl)methyl)-3-methylimidazolidine-2,4-dione

参考文献

1. Degterev A, et al. Nat Chem Biol. 2005 Jul;1(2):112-9.

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