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首页-小分子抑制剂&激动剂-GPCR-Endothelin Receptor-Nebentan
Nebentan

Chemical Structure : Nebentan

CAS No.: 342005-82-7

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Nebentan (YM598, Nebentan potassium)

货号: PC-28489Not For Human Use, Lab Use Only.

Nebentan (Nebentan potassium, YM598) is a potent, selective and orally active non-peptide endothelin ETA receptor antagonist, inhibits [125I] endothelin-1 binding to cloned human ETA receptor with Ki of 0.697 nM, >800-fold selective over ETB receoptor.

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5 mg ￥1280 In stock
10 mg ￥1980 In stock
25 mg ￥3480 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Nebentan (Nebentan potassium, YM598) is a potent, selective and orally active non-peptide endothelin ETA receptor antagonist, inhibits [125I] endothelin-1 binding to cloned human ETA receptor with Ki of 0.697 nM, >800-fold selective over ETB receoptor.

物理化学性质&存储条件

分子量 529.61
分子式 C24H20KN5O5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

potassium (E)-(6-methoxy-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)(styrylsulfonyl)amide

参考文献

1. Hironori Yuyama, et al. Eur J Pharmacol. 2003 Sep 30;478(1):61-71.

2. Akira Fujimori, et al.J Cardiovasc Pharmacol. 2004 Nov;44 Suppl 1:S354-7.

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