Navoximod (GDC-0919, NLG-919) | IDO1 inhibitor | Probechem Biochemicals

Chemical Structure : Navoximod

CAS No.: 1402837-78-8

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Navoximod (GDC-0917, NLG-919, CUDC427, CUDC-427)

货号: PC-45552Not For Human Use, Lab Use Only.

Navoximod (GDC-0919, NLG-919) is a potent, selective inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1) with biochemical IC50 of 28 nM, and of Ki of 5.8 nM.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4880	In stock
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100 mg		Get quote

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生物&药学活性

Navoximod (GDC-0919, NLG-919) is a potent, selective inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1) with biochemical IC50 of 28 nM, and of Ki of 5.8 nM.

NLG-919 inhibits IDO1 activity in an uncompetitive or a noncompetitive mode with respect to the l-Trp substrate.

NLG-919 (500 mg/kg/day) reduced tumor growth and enhance survival as a single agent in Pan02 tumor model in C57Bl/6 mice.

物理化学性质&存储条件

分子量	316.3699
分子式	C18H21FN2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO: 100 mg/mL
Chemical Name/SMILES	5H-Imidazo[5,1-a]isoindole-5-ethanol, 6-fluoro-α-(trans-4-hydroxycyclohexyl)-, (αR,5S)-

参考文献

1. Mautino, et al. Preparation of fused imidazole derivatives as IDO inhibitors. From PCT Int. Appl. (2012), 20121018.
2. Kumar S, et al. J Med Chem. 2019 Jul 25;62(14):6705-6733.

Navoximod (GDC-0917, NLG-919, CUDC427, CUDC-427)

生物&药学活性

物理化学性质&存储条件

参考文献

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Navoximod (GDC-0917, NLG-​919, CUDC427, CUDC-427)

生物&药学活性

物理化学性质&存储条件

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Navoximod (GDC-0917, NLG-919, CUDC427, CUDC-427)