Nav1.5 inhibitor KH2

Chemical Structure : Nav1.5 inhibitor KH2

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货号: PC-27210Not For Human Use, Lab Use Only.

Nav1.5 inhibitor KH2 is an effective Nav1.5 inhibitor with IC50 of 1.38 uM, reduces cardiac conduction.

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25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Nav1.5 inhibitor KH2 is an effective Nav1.5 inhibitor with IC50 of 1.38 uM, reduces cardiac conduction.
KH2 significantly lowered acitivity against different Nav subtypes as hNav1.2 (IC50 = 5.72 μM), hNav1.4 (IC50 = 5.38 μM), hNav1.7 (IC50 = 7.61 μM), and hNav1.9 (IC50 = 9.73 μM).
KH2 reduced the conduction velocity of the left atrium in isolated rat hearts.
KH2 could modulate the conduction velocity of both atria and ventricles by blocking sodium channels, thereby altering the processes of depolarization and repolarization in the heart.

物理化学性质&存储条件

分子量	642.21
分子式	C36H36ClN3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-(4-benzylpiperidin-1-yl)propyl)-10-(3-chlorobenzyl)-11-oxo-10,11-dihydrodibenzo[b,f][1,4]thiazepine-8-carboxamide 5,5-dioxide

参考文献

1. Wang YY, et al. Acta Pharmacol Sin. 2026 Apr;47(4):990-998.