Nateglinide | DPP IV inhibitor | Probechem Biochemicals

Chemical Structure : Nateglinide

CAS No.: 105816-04-4

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Nateglinide (Senaglinide, DJN-608, A-4166)

货号: PC-20822Not For Human Use, Lab Use Only.

Nateglinide (Senaglinide, DJN-608, A-4166) is an oral hypoglycaemic agent and non-sulphonylurea insulin secretagogue, also is a MRGPRX4 agonist.

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200 mg	￥2880	In stock
500 mg	￥4580	In stock
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生物&药学活性

Nateglinide (Senaglinide, DJN-608, A-4166) is an oral hypoglycaemic agent and non-sulphonylurea insulin secretagogue and DPP IV inhibitor, also is a MRGPRX4 agonist.
Nateglinide (Senaglinide, DJN-608, A-4166) stimulated insulin secretion from rat freshly isolated pancreatic islets at concentrations from 3-300 uM in the presence of 2.8 uM glucose.
Nateglinide (Senaglinide, DJN-608, A-4166) displaced [3H]-glibenclamide bound to intact HIT-T15 cells in a concentration-dependent manner with Ki of 434 nM.
Nateglinide (Senaglinide, DJN-608, A-4166) (1-10 mg/kg, oral) showed a dose-dependent hypoglycaemic effect in fasted beagle dogs.

物理化学性质&存储条件

分子量	317.43
分子式	C19H27NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R)-3-phenyl-2-[(4-propan-2-ylcyclohexanecarbonyl)amino]propanoic acid

参考文献

1. Shinkai H, et al. J Med Chem. 1989 Jul;32(7):1436-41.

2. Ikenoue T, et al. Br J Pharmacol. 1997 Jan;120(1):137-45.

Nateglinide (Senaglinide, DJN-608, A-4166)

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物理化学性质&存储条件

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Nateglinide (Senaglinide, DJN-608, A-4166)

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