Naronapride |CAS:860174-12-5 Probechem Biochemicals

Chemical Structure : Naronapride

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Naronapride (ATI-7505, ATI 7505)

货号: PC-62096Not For Human Use, Lab Use Only.

Naronapride (ATI-7505) is a potent, selective and orally active 5-HT4 receptor agonist with Ki of 1.4 nM.

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生物&药学活性

Naronapride (ATI-7505) is a potent, selective and orally active 5-HT4 receptor agonist with Ki of 1.4 nM.
Naronapride (ATI-7505) displays negligible affinity for Kv11.1 channels (Ki=24,500 nM), and no effect on cardiac repolarization.
Naronapride (ATI-7505) shows potential for treatment of gastrointestinal motility disorders.

物理化学性质&存储条件

分子量	537.098
分子式	C27H41ClN4O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	[(3R)-1-azabicyclo[2.2.2]octan-3-yl] 6-[(3S,4R)-4-[(4-amino-5-chloro-2-methoxybenzoyl)amino]-3-methoxypiperidin-1-yl]hexanoate

参考文献

1. Manabe N, et al. Expert Opin Investig Drugs. 2010 Jun;19(6):765-75.

2. Bowersox SS, et al. Drug Metab Dispos. 2011 Jul;39(7):1170-80.

3. Hoffman JM, et al. Gastroenterology. 2012 Apr;142(4):844-854.e4.

4. Camilleri M, et al. Neurogastroenterol Motil. 2007 Jan;19(1):30-8.

Naronapride (ATI-7505, ATI 7505)

生物&药学活性

物理化学性质&存储条件

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Naronapride (ATI-7505, ATI 7505)

生物&药学活性

物理化学性质&存储条件

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