Narlaprevir | HCV NS3 protease inhibitor | Probechem Biochemicals

Chemical Structure : Narlaprevir

CAS No.: 865466-24-6

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Narlaprevir (SCH900518, SCH-900518)

货号: PC-42515Not For Human Use, Lab Use Only.

Narlaprevir (SCH900518) is a potent, second generation HCV NS3 serine protease inhibitor with Ki of 6 nM.

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5 mg	￥2880	In stock
10 mg	￥4580	In stock
25 mg	￥7580	In stock
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生物&药学活性

Narlaprevir (SCH900518) is a potent, second generation HCV NS3 serine protease inhibitor with Ki of 6 nM.
Narlaprevir displays no significant issues in the in vitro CYP or hERG assay.
Narlaprevir shows replicon EC90 of 40 nM; exhibits improved potency (∼10-fold over Boceprevir), pharmacokinetic profile and physicochemical characteristics.

物理化学性质&存储条件

分子量	707.9639
分子式	C36H61N5O7S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-Azabicyclo[3.1.0]hexane-2-carboxamide, N-[(1S)-1-[2-(cyclopropylamino)-2-oxoacetyl]pentyl]-3-[(2S)-2-[[[[1-[[(1,1-dimethylethyl)sulfonyl]methyl]cyclohexyl]amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-, (1R,2S,5S)-

参考文献

1. Arasappan A, et al. ACS Med Chem Lett. 2010 Feb 15;1(2):64-9.

2. Tong X, et al. Antimicrob Agents Chemother. 2010 Jun;54(6):2365-70.

3. de Bruijne J, et al. Hepatology. 2010 Nov;52(5):1590-9.

Narlaprevir (SCH900518, SCH-900518)

生物&药学活性

物理化学性质&存储条件

参考文献

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Narlaprevir (SCH900518, SCH-900518)

生物&药学活性

物理化学性质&存储条件

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