Naquotinib (ASP8273) | EGFR inhibitor | Probechem Biochemicals

Chemical Structure : Naquotinib

CAS No.: 1448232-80-1

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Naquotinib (ASP8273, ASP-8273)

货号: PC-45689Not For Human Use, Lab Use Only.

Naquotinib (ASP-8273) is a potent, irreversible, mutant-selective inhibitor of EGFR (IC50=8-33 nM for (L858R, exon 19 deletion, L858R/T790M, and del19/T790M)).

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5 mg	￥880	In stock
10 mg	￥1380	In stock
25 mg	￥2480	In stock
50 mg	￥3980	In stock
100 mg		Get quote

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生物&药学活性

Naquotinib (ASP-8273) is a potent, irreversible, mutant-selective inhibitor of EGFR (IC50=8-33 nM for (L858R, exon 19 deletion, L858R/T790M, and del19/T790M)).
Naquotinib (ASP-8273) is more potently than that of WT EGFR (IC50= 230 nM).
Naquotinib (ASP-8273) shows activity in mutant EGFR cell line which is resistant to other EGFR TKIs including AZD9291 and CO-1686.

物理化学性质&存储条件

分子量	562.7063
分子式	C30H42N8O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 100 mM (56.2 mg/mL)
Chemical Name/SMILES	2-Pyrazinecarboxamide, 6-ethyl-3-[[4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-5-[[(3R)-1-(1-oxo-2-propen-1-yl)-3-pyrrolidinyl]oxy]-

参考文献

1. Wang S, et al. J Hematol Oncol. 2016 Apr 12;9:34.

Naquotinib (ASP8273, ASP-8273)

生物&药学活性

物理化学性质&存储条件

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Naquotinib (ASP8273, ASP-8273)

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物理化学性质&存储条件

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