Naltrexone

Chemical Structure : Naltrexone

CAS No.: 16590-41-3

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货号: PC-45979Not For Human Use, Lab Use Only.

Naltrexone is a potent, competitive antagonist for μ, κ, δ, and σ-opioid receptors with Ki of 0.0825 nM, 0.509 nM, and 8.02 nM, for MOR, KOR, and DOR, respectively.

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50 mg	￥480	In stock
100 mg	￥680	In stock
250 mg	￥980	In stock
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Naltrexone is a potent, competitive antagonist for μ, κ, δ, and σ-opioid receptors with Ki of 0.0825 nM, 0.509 nM, and 8.02 nM, for MOR, KOR, and DOR, respectively.
Naltrexone also inhibits IL-6 and TNFα production in human immune cell subsets following stimulation with ligands for intracellular TLRs.
Naltrexone is a TLR-4 antognist that inhibits LPS-induced TLR4 downstream NO production in microglia BV-2 cells (IC50=105 uM).

物理化学性质&存储条件

分子量	341.4009
分子式	C20H23NO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO: ≥ 31 mg/mL
Chemical Name/SMILES	Morphinan-6-one, 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-, (5α)-

参考文献

1. Codd EE, et al. J Pharmacol Exp Ther. 1995 Sep;274(3):1263-70.

2. Cant R, et al. Front Immunol. 2017 Jul 11;8:809.

3. Selfridge BR, et al. J Med Chem. 2015 Jun 25;58(12):5038-52.

Naltrexone

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Naltrexone

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