Nafamostat mesylate (FUT-175)

Chemical Structure : Nafamostat mesylate

CAS No.: 82956-11-4

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货号: PC-47020Not For Human Use, Lab Use Only.

Nafamostat mesylate (FUT-175) is a synthetic serine protease inhibitor with anticoagulant, anti-inflammatory, mucus clearing, and potential antiviral activities, blocks SARS-CoV-2 infection of Calu-3 cells with IC50 of 10 nM.

规格	价格	库存
25 mg	￥580	In stock
50 mg	￥880	In stock
100 mg	￥1380	In stock
250 mg		Get quote

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生物&药学活性

Nafamostat mesylate (FUT-175) is a synthetic serine protease inhibitor with anticoagulant, anti-inflammatory, mucus clearing, and potential antiviral activities, blocks SARS-CoV-2 infection of Calu-3 cells with IC50 of 10 nM.
Nafamostat mesylate potently inhibits SARS-CoV-2 S protein-mediated fusion in a cell fusion assay system and also inhibits SARS-CoV-2 infection in vitro in a cell-type-dependent manner.

物理化学性质&存储条件

分子量	539.6
分子式	C21H25N5O8S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[(Aminoiminomethyl)amino]benzoic acid 6-(aminoiminomethyl)-2-naphthalenyl ester dimethanesulfonate

参考文献

1. Hoffmann M, et al. Antimicrob Agents Chemother. 2020 May 21;64(6):e00754-20.

2. Zhou H, et al. Br J Pharmacol. 2020 Jul;177(14):3147-3161.

3. Yamamoto M, et al. Viruses. 2020 Jun 10;12(6):629.

4. Markus Hoffmann, et al. Cell. 2020 Apr 16;181(2):271-280.e8.