NaPi2b inhibitor 15

Chemical Structure : NaPi2b inhibitor 15

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货号: PC-73331Not For Human Use, Lab Use Only.

NaPi2b inhibitor 15 is an orally administrable small-molecule NaPi2b (NaPi-2b, SLC34A2) inhibitor, inhibits phosphate uptake in vitro with IC50 of 64 nM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

NaPi2b inhibitor 15 is an orally administrable small-molecule NaPi2b (NaPi-2b, SLC34A2) inhibitor, inhibits phosphate uptake in vitro with IC50 of 64 nM.
NaPi2b inhibitor 15 showed a low bioavailability (F = 0.1%) in rats and a reduction in phosphate absorption in the rat intestinal loop assay comparable to sevelamer hydrochloride.

物理化学性质&存储条件

分子量	943.470
分子式	C44H58ClF3N4O11S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-1-(3-((3-(2-(4-chloro-3-(trifluoromethyl)benzylidene)hydrazine-1-carbonyl)-6,6-dimethyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)carbamoyl)phenyl)-20-(2-methoxyethyl)-2,5,8,11,14,17-hexaoxa-20-azadocosan-22-oic acid

参考文献

1. Michihiro Maemoto, et al. J Med Chem. 2022 Feb 10;65(3):1946-1960.