NZ-804 | SARS-CoV-2 Mpro inhibitor | Probechem Biochemicals

Chemical Structure : NZ-804

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NZ-804 (NZ804)

货号: PC-23375Not For Human Use, Lab Use Only.

NZ-804 is a potent, selective, non-peptidic, non-covalent inhibitor of SARS-CoV-2 main protease (Mpro) with IC50 of 9 nM and antiviral EC50 of 14 nM.

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生物&药学活性

NZ-804 is a potent, selective, non-peptidic, non-covalent inhibitor of SARS-CoV-2 main protease (Mpro) with IC50 of 9 nM and antiviral EC50 of 14 nM.
NZ-804 has potent and broad activity against the CoV family, exerts antiviral activity against pandemic, epidemic, endemic, and enzootic CoVs, including pandemic SARS-CoV-2 D614G (NZ-804 EC50 = 0.009 μM, Nirm EC50 = 0.03 μM); SARS-CoV-2 WA1 (NZ-804 EC50 = 0.01 μM); SARS-CoV-2-like pangolin CoV PgCoV (NZ-804 EC50 = 0.006 μM, Nirm EC50 = 0.02 μM); SARS-CoV-like bat CoV WIV1 (NZ-804 EC50 = 0.002 μM, Nirm EC50 = 0.02 μM), and SARS-CoV-like bat CoV SHC014 (NZ-804 EC50 = 0.007 μM, Nirm EC50 = 0.03 μM).
NZ-804 does not select for specific resistance in SARS-CoV-2. NZ-804 retains inhibition of mutant Mpro enzyme that is resistant to Nirm (Paxlovid).
NZ-804 effectively reduced SARS-CoV-2 replication and pathogenesis, reduces SARS-CoV-2 replication and pathogenesis in mice.

物理化学性质&存储条件

分子量	469.56
分子式	C27H23N3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4-(5,5-dioxidodibenzo[b,e]thiepin-11(6H)-ylidene)piperidin-1-yl)(1H-pyrrolo[3,2-c]pyridin-7-yl)methanone

参考文献

1. Zhou NE, et al. Cell Rep. 2024 Nov 5;43(11):114929.

NZ-804 (NZ804)

生物&药学活性

物理化学性质&存储条件

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NZ-804 (NZ804)

生物&药学活性

物理化学性质&存储条件

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