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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Proton Pump-NZ-58
NZ-58

Chemical Structure : NZ-58

CAS No.: 1609523-20-7

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NZ-58

货号: PC-26887Not For Human Use, Lab Use Only.

NZ-58 is a small molecule inhibitor of the HV1 voltage-gated proton channel with IC50 of 8.5 uM, also potently blocks voltage-gated Na+ and K+ channels at 50 uM, acts as a pan-VSD (voltage-sensor domains) modulator.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

NZ-58 is a small molecule inhibitor of the HV1 voltage-gated proton channel with IC50 of 8.5 uM, also potently blocks voltage-gated Na+ and K+ channels at 50 uM, acts as a pan-VSD (voltage-sensor domains) modulator.
NZ-58 induces complete inhibition of multiple ion channels, including VGICs NaV1.5, NaV1.2, NaV1.4, KV1.3, fast inactivation-removed KV1.4, KV1.5, KV11.1 (hERG), as well as the non-voltage-gated Kir2.1 and KCa3.1 channels, in whole-cell patch clamp at 50 uM.

物理化学性质&存储条件

分子量 401.35
分子式 C19H14F3N5O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(3-(2-amino-1H-imidazol-5-yl)phenyl)-5-(trifluoromethoxy)-1H-indole-2-carboxamide

参考文献

1. Geraldo Jorge Domingos, et al. Biomed Pharmacother. 2026 May 20:200:119530.

2. M. Piga, et al. J. Chem. Inf. Model. (2024)

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